Sen CK, Gordillo GM, Roy S Human skin wounds: A major and snowballing threat to public health and the economy: Perspective Article. Wound Repair Regen. 2009; 17:(6)763-771
Sibbald RG, Elliott JA, Ayello EA, Somayaji R. Optimizing the moisture management tightrope with wound bed preparation 2015. Adv Ski Wound Care. 2015; 28:(10)466-476
Gottrup F, Apelqvist J, Bjansholt T EWMA Document: Evidence, controversies and suggestions. J Wound Care. 2013; 22:(5)S1-S89
Singer AJ, Clark RAF. Cutaneous Wound Healing. N Engl J Med. 1999; 341:(10)738-746
Guarin-Corredor C, Quiroga-Santamaria P, Landinez-Parra N. Proceso de cicatrizacion de heridas de piel, campos endógenos y su relación con las heridas crónicas. Rev la Fac Med. 2013; 61:441-448
Wallace HA, Basehore BM, Zito PM. Wound Healing Phases.: StatPearls Publishing; 2021
Jaul E. Non-healing wounds: The geriatric approach. Arch Gerontol Geriatr. 2009; 49:(2)224-226
Bhandari M, Giannoudis PV. Evidence-based medicine: What it is and what it is not. Injury. 2006; 37:(4)302-306
Sibbald RG, Williamson D, Orsted HL Preparing the wound bed: debridement, bacterial balance, and moisture balance. Ostomy Wound Manage. 2000; 46:(11)14-37
Sibbald RG, Elliott JA, Persaud-Jaimangal R Wound Bed Preparation 2021. Adv Skin Wound Care. 2021; 34:(4)183-195
Barrett S. Wound-bed preparation: A vital step in the healing process. Br J Nurs. 2017; 26:(12)S24-S31
Atkin L, Bucko Z, Conde Montero E Implementing TIMERS: the race against hard-to-heal wounds inflammation/infection social factors. Edge Regeneration Moisture Tissue. J Wound Care. 2019; 28:(3)S1-S50
Swanson T, Angel D. Wound Infection in Clinical Practice Update. Aust Nurs Midwifery J. 2017; 24:(8)
Wolcott RD, Kennedy JP, Dowd SE. Regular debridement is the main tool for maintaining a healthy wound bed in most chronic wounds. J Wound Care. 2009; 18:(2)54-56
Leaper DJ, Schultz G, Carville K Extending the TIME concept: What have we learned in the past 10 years?. Int Wound J. 2012; 9:1-19
Atiyeh BS, Dibo SA, Hayek SN. Wound cleansing, topical antiseptics and wound healing. Int Wound J. 2009; 6:(6)420-430
Bianchi J. The cleansing of superficial traumatic wounds. Wounds. 2004; 2000:22-25
Murphy C, Atkin L, Swanson T International consensus document. Defying hard-to-heal wounds with an early antibiofilm intervention strategy: wound hygiene. J Wound Care. 2020; 29:S1-S28
Siddiqui AR, Bernstein JM. Chronic wound infection: Facts and controversies. Clin Dermatol. 2010; 28:(5)519-526
Ashiru-Oredope D, Cookson B, Fry C Developing the first national antimicrobial prescribing and stewardship competences. J Antimicrob Chemother. 2014; 69:(11)2886-2888
Levine JM. Dakin's Solution: past, present, and future. 2013; 26:(9)410-414
Daeschlein G, Assadian O, Bruck JC Feasibility and clinical applicability of polihexanide for treatment of second-degree burn wounds. Skin Pharmacol Physiol. 2007; 20:(6)292-296
Ince A, Schütze N, Hendrich C Effect of polyhexanide and gentamycin on human osteoblasts and endothelial cells. Swiss Med Wkly. 2007; 137:(9–10)139-145
Schultz G, Weir D, Lee Ruotsi C The clinical efficacy of pure hypochlorous acid preservative-based wound solutions. Wound Source. 2021; 11:(29)
Wang L, Bassiri M, Najafi R Hypochlorous acid as a potential wound care agent: part I. Stabilized hypochlorous acid: a component of the inorganic armamentarium of innate immunity. J Burns Wounds. 2007; 6
Brennan SS, Leaper DJ. The effect of antiseptics on the healing wound: A study using the rabbit ear chamber. Br J Surg. 1985; 72:(10)780-782
Balard AJ.: EDP Sciences; 2020
Gottardi W, Nagl M. N-chlorotaurine, a natural antiseptic with outstanding tolerability. J Antimicrob Chemother. 2010; 65:(3)399-409
Coraça-Huber DC, Ammann CG, Fille M Bactericidal activity of N-chlorotaurine against biofilm-forming bacteria grown on metal disks. Antimicrob Agents Chemother. 2014; 58:(4)2235-2239
Steadman M. The scientific bases for the use of hypochlorous acid to avoid pitfalls proceedings of a symposium of investigators. Wounds. 2019;
Denys GA, Carpenter JL, Allen RC, Stephens JT. Antiseptic action of E-101 solution, a myeloperoxidase-mediated formulation in the presence of whole blood compared to conventional wound antiseptics and biocides. Journal of Antimicrobial Agents. 2021; 7:3-8
Stanton S. Disinfection, sterilization, and preservation, 5th ed. : Lippincott Williams & Wilkins; 2001
Hall-Stoodley L, Stoodley P. Biofilm formation and dispersal and the transmission of human pathogens. Trends Microbiol. 2005; 13:(1)7-10
James GA, Swogger E, Wolcott R Biofilms in chronic wounds. Wound Repair Regen. 16:(1)37-44
Dowd SE, Sun Y, Secor PR Survey of bacterial diversity in chronic wounds using pyrosequencing, DGGE, and full ribosome shotgun sequencing. BMC Microbiol. 2008; 8:1-15
Wolcott RD, Rhoads DD, Dowd SE. Biofilms and chronic wound inflammation. J Wound Care. 2008; 17:(8)333-341
Percival SL, McCarty SM, Lipsky B. Biofilms and Wounds: An overview of the evidence. Adv Wound Care. 2015; 4:(7)373-381
James GA, Ge Zhao A, Usui M Microsensor and transcriptomic signatures of oxygen depletion in biofilms associated with chronic wounds. Wound Repair Regen. 2016; 24:(2)373-383
Nerandzic MM, Rackaityte E, Jury LA. Novel strategies for enhanced removal of persistent bacillus anthracis surrogates and clostridium difficile spores from skin. PLoS One. 2013; 8:(7)1-9
Robson MC. Treating chronic wounds with hypochlorous acid disrupts biofilm.: WoundClinic; 2014
Davis SC, Gil J, Li J Effect of mechanical debridement and irrigation with hypochlorous acid wound management solution on methicillin-resistant staphylococcus aureus contamination and healing deep dermal wounds in a porcine model. Wound Manag Prev. 2021; 67:(8)24-31
Miller C, Mouhlas A. Significant cost savings realized by changing debridement protocol. Ostomy Wound Manag. 2014; 8-9
Mallow PJ, Hiebert JM, Robson MC. Cost-effectiveness of hypochlorous acid preserved wound cleanser versus saline irrigation in conjunction with ultrasonic debridement for complex wounds. J Heal Econ Outcomes Res. 2021; 8:(2)76-81
Dharap SB, Ghag GS, Kulkarni KP, Venkatesh V. Efficacy and safety of oxum in treatment of the venous ulcer. J Indian Med Assoc. 2008; 106:(5)326-330
Fluhr JW, Darlenski R. Skin surface pH in newborns: origin and consequences. Curr Probl Dermatology. 2018; 54:26-32
Nagoba B, Suryawanshi N, Wadher SS. Acidic enviroment and wound healing: a review. Wounds. 2015; 27:(1)5-11
Seal LA, Robson MC. The influence of pH on chronic wound healing and the antimicrobial activity of chlorine. Ostomy Wound Manag. 2018; 8-10
Lafaurie GI, Calderón JL, Zaror C Ácido hipocloroso: una nueva alternativa como agente antimicrobiano y para la proliferación celular para uso en odontología. Int J Odontostomatol. 2015; 9:(3)475-481
Sakarya S, Gunay N, Karakulak M Hypochlorous acid: An ideal wound care agent with powerful microbicidal, antibiofilm, and wound healing potency. Wounds. 2014; 26:(12)342-350
Beeckman D, Campbell J, Campbell K Incontinence-associated dermatitis: moving prevention forward.: Wounds International; 2015
Marshall-Hanson C. Healing complex wounds and skin conditions in pediatric patients using a pH-controlled cleanser containing hypochlorous acid. Wound Management & Prevention. 2020; 66:(7)8-10
Greenstein E. Adding a hypochlorous acid-preserved wound cleanser to the pressure injury management toolbox: A case series. Wound Manag Prev. 2021; 67:(5)8-12
International Best Practice Guidelines: Effective skin and wound management of non-complex burns.: Wounds International; 2014
Abdel-Sayed P, Tornay D, Hirt-Burri N Implications of chlorhexidine use in burn units for wound healing. Burns. 2020; 46:(5)1150-1156
Delapena S, Fernández LG, Foster KN, Matthews MR. Negative pressure wound therapy with instillation and dwell time for the management of complex wounds: A case series. Index Wounds. 2020; 32:(12)E96-E100
Otero A, Valentin R. Absence of infection in orthopedic surgical wounds irrigated with hypochlorous acid. Ostomy Wound Manag. 2016; 24:(4)1-2
Crew JR, Thibodeaux KT, Speyrer MS Flow-through instillation of hypochlorous acid in the treatment of necrotizing fasciitis. Wounds. 2016; 28:(2)40-47
Matthews MR, Quan AN, Shah AR Hypochlorous acid for septic abdominal processes using a unique negative pressure wound therapy system: A pilot study. Surg Sci. 2018; 09:(11)412-421
Desvigne MN. Hypochlorous acid: A practical choice for instillation with negative pressure wound therapy when surgical closure is anticipated. 2020; 66:(3)
Faust E. Healing complex wounds from necrotizing fasciitis using the combination of negative pressure wound therapy with instillation and dwell and a hypochlorous acid solution. 2021;
Matthews MR, Quan AN, Weir AS Temporary abdominal closure combined with an irrigating system utilizing hypochlorous acid solution to decrease abdominal mucopurulence. Eplasty. 2018; 18
Fernandez L, Matthews M, Seal L. Intraabdominal lavage of hypochlorous acid a new paradigm for the septic and open abdomen. Wounds. 2020; 32:(4)107-114
Gold MH, Andriessen A, Bhatia AC Topical stabilized hypochlorous acid: The future gold standard for wound care and scar management in dermatologic and plastic surgery procedures. J Cosmet Dermatol. 2020; 19:(2)270-277
Robson MC, Payne WG, Ko F Hypochlorous acid as a potential wound care agent: Part II. Stabilized hypochlorous acid: Its role in decreasing tissue bacterial bioburden and overcoming the inhibition of infection on wound healing. J Burns Wounds. 2007; 6